Huntington's chorea yog ib yam kab mob uas muaj tus kab mob hauv lub cev, nrog rau kev pom ntawm kev tsis sib haum, kev txo qis hauv kev txawj ntse thiab kev tsim kho mob hlwb. Tus kab mob no tuaj yeem tsim muaj nyob rau hauv cov txiv neej thiab cov poj niam thaum muaj hnub nyoog li cas, tab sis feem ntau thawj cov tsos mob ntawm Huntington's chorea tshwm sim hauv cov hnub nyoog 35-40 xyoos.
Cov tsos mob ntawm Huntington's Disease
Lub ntsiab lus tseem ceeb ntawm Huntington tus kab mob yog chorea, uas yog pom los ntawm kev tsis sib haum thiab tsis tswj tsis tau. Thaum xub thawj, cov no tsuas yog muaj teeb meem me me hauv kev sib koom tes nrog lub zog ntawm tes lossis taw. Cov kev hloov no yuav ua tau qeeb qeeb lossis qis zog. Maj mam, lawv muab tag nrho lub cev thiab zaum ntsiag to, noj mov los yog hnav ris tsho ua tsis tiav. Tom qab ntawd, lwm cov tsos mob ntawm Huntington tus kab mob yuav pib muab rau tus mob no:
- teeb meem nrog cov txheej txheem kev zom thiab nqos;
- hais lus xiam oob qhab;
- teeb meem nrog pw;
- ua txhaum ntawm cov leeg mob.
Thaum theem pib, tej zaum yuav muaj kev tsis sib haum xeeb thiab kev txawj ntse. Piv txwv, tus neeg mob tau ua txhaum txoj haujlwm ntawm kev xav tsis zoo. Yog li ntawd, nws tsis tuaj yeem npaj ua haujlwm, ua haujlwm rau lawv thiab muab kev tshuaj ntsuam kom txaus. Tom qab ntawd tus mob ua rau mob hnyav dua: ib tug neeg ua nruj ua tsiv, deev tsis sib deev, tsis muaj tswv yim, muaj tswv yim tshwm sim thiab quav tshuaj (kev quav dej caw, kev twv txiaj).
Kev kuaj ntawm Huntington's Disease
Kev kuaj ntawm Huntington's syndrome yog siv ntau txoj kev soj ntsuam kev xav ntawm lub paj hlwb thiab kev kuaj mob. Ntawm cov kev siv twj paj nruas, qhov chaw tseem ceeb yog los ntawm kev sib nqus resonance duab thiab computed tomography. Nws yog nrog lawv cov kev pab uas koj tuaj yeem pom qhov chaw ntawm lub hlwb puas tsuaj.
Genetic testing yog siv los ntawm kev ntsuam xyuas txoj kev. Yog tias ntau tshaj li 38 trinucleotide seem ntawm CAG raug kuaj pom hauv cov noob H HD, ces Huntington tus kab mob yuav tshwm sim hauv 100% ntawm tus neeg mob. Nyob rau hauv cov ntaub ntawv no, lub me qhov ntau ntawm cov seem, tom qab nyob rau hauv lub neej tom qab yuav manifest chorea.
Kev kho mob ntawm Huntington's Disease
Hmoov tsis, Huntington tus kab mob yog tsis kho. Thaum lub sij hawm, nyob rau hauv kev sib ntaus tawm tsam tus kab mob no, tsuas yog symptomatic txoj kev kho yog siv, uas mus ib ntus facilitates tus neeg mob lub mob.
Qhov zoo tshaj plaws siv yeeb tshuaj, weakening cov tsos mob ntawm tus kab mob, yog Tetrabenazine. Tsis tas li ntawd nyob rau hauv txoj kev kho mob yog cov yeeb tshuaj tiv thaiv Anti-Parkinsonian:
- Bromocriptine;
- Levodopa;
- Pergolid.
Txhawm rau tshem tawm hyperkinesia thiab txo cov nqaij rigidity, valproic acid yog siv. Kev kho rau kev nyuaj siab nyob rau hauv tus kab mob no yog nqa nrog Prozac, Citalopram, Zoloft thiab lwm yam tshuaj serotonin reuptake inhibitors. Thaum tsim kev puas siab puas ntsws, atypical antipsychotics (Risperidone, Clozapine los yog Amisulpride).
Lub neej muaj kev cia siab rau cov neeg uas raug kev txom nyem los ntawm Huntington's kab mob yog txo kom tsawg. Txij lub sijhawm pib ntawm cov tsos mob ntawm thawj cov kev mob ntawm txoj kev tuag los ntawm kev tuag tau dhau 15 xyoos xwb. Nyob rau tib lub sijhawm, ua rau tuag taus
- suicidal npaj siab;
- mob ntsws o;
- pathology ntawm lub plawv.
Vim tias qhov no yog ib hom kab mob caj ces, kev tiv thaiv nws tus kheej tsis muaj nyob. Tiam sis los ntawm kev siv txoj kev kuaj xyuas (kev kuaj ntshav nrog DNA kuaj) nws tsis yog qhov tsim nyog yuav tsum tsis kam, vim yog thaum ntxov thaum pib pib kho mob, koj tuaj yeem ntev lub neej ntawm tus neeg mob.