Cov lus sau ntawm txhua lub hlwb ntawm lub cev muaj esters ntau dua fatty acids thiab polyhydric alcohols. Cov tshuaj chiv no yog hu ua phospholipids, lawv muaj lub luag haujlwm los tuav lub qauv ntawm cov ntaub so ntswg, koom rau hauv cov txheej txheem metabolic thiab nyob rau hauv kev sib cais ntawm cov cholesterol. Qhov kev noj qab haus huv yog nyob ntawm cov ntsiab lus ntawm cov tshuaj no.
AFS-syndrome - nws yog dabtsi?
Kwv yees li 35 xyoo dhau los, rheumatologist Graham Hughes pom ib tug pathology uas lub cev tiv thaiv kab mob pib tsim hom tshuaj tiv thaiv tawm tsam phospholipids. Lawv muab xa mus rau platelets thiab vascular phab ntsa, cuam tshuam nrog cov nqaijrog, nkag mus rau hauv cov metabolic thiab cov ntshav khaus. Ob leeg thij ob thiab thawj lub npe ntawm cov tshuaj tiv thaiv antiphospholipid yog ib hom kab mob autoimmune ntawm lub hauv paus uas tsis pom. Qhov teeb meem no feem ntau yuav cuam tshuam rau cov poj niam hauv lub hnub nyoog.
Antiphospholipid Syndrome - ua rau
Rau rheumatologists tsis tau nws tsis tau tsim, yog vim li cas muaj ib tug mob los yog kab mob. Muaj cov lus qhia tias antiphospholipid syndrome feem ntau pom muaj nyob rau hauv cov txheeb ze uas muaj kev tsis zoo sib xws. Ntxiv nrog rau heredity, kws txawj qhia ob peb lwm yam uas provoke pathology. Nyob rau hauv xws li no, ib qib AFS tshwm sim - qhov ua rau cov tshuaj tiv thaiv antibody muaj xws li kev mob ntawm lwm cov kab mob uas cuam tshuam kev ua haujlwm ntawm lub cev. Lub tswv yim ntawm txoj kev kho yog nyob ntawm cov mechanisms ntawm qhov pib ntawm tus kab mob.
Thawj tus kab mob antiphospholipid syndrome
Hom kab mob no tau tsim tawm ntawm nws tus kheej, thiab tsis tawm tsam ntawm qee yam mob hauv lub cev. Qhov mob ntawm tus kab mob antiphospholipid antibodies yog ib qho nyuaj rau kev kho mob vim yog tsis muaj kev kub ntxhov. Feem ntau thawj hom kab mob ntawm cov kab mob no yuav luag tsis paub txog asymptomatic thiab yog kuaj tau yav tas los ntawm kev mob qeeb zog los yog thaum muaj teeb meem.
Qhov tshuaj tiv thaiv antiphospholipid syndrome
Qhov sib txawv ntawm cov tshuaj tiv thaiv mob autoimmune vim yog muaj lwm cov kab mob hauv lub cev los yog tej yam xwm txheej raug mob. Lub impetus mus rau thaum pib ntawm pathological txoj kev loj hlob ntawm cov tshuaj tiv thaiv tau txawm tias yuav conception. Antiphospholipid syndrome nyob rau hauv cov poj niam cev xeeb tub muaj nyob hauv 5% ntawm tus neeg mob. Yog tias tus kab mob nug tau ntxov dua, kev coj tus cwj pwm zoo yuav ua rau nws mob siab.
Cov kab mob uas muaj lub siab xav ua kom muaj tus kab mob antiphospholipid syndrome:
- kis kab mob thiab kis kab mob;
- oncological neoplasms;
- nodular periarteritis;
- kev mob lupus erythematosus.
Antiphospholipid syndrome - cov tsos mob ntawm cov poj niam
Cov duab saib ntawm pathology yog qhov ntau heev thiab tsis txawv, uas ua rau cov teeb meem sib txawv sib txawv. Qee lub sij hawm qhov teeb meem no tshwm sim yam tsis muaj ib qho kev qhia, tiam sis feem ntau antiphospholipid syndrome no tshwm sim hauv nws tus kheej ntawm cov kab mob ntsws los ntawm cov hlab ntsha thiab cov hlab ntsha (hlab ntsha los yog leeg):
- qis nquag;
- nplooj siab;
- retina;
- lub hlwb;
- lub plawv;
- lub teeb;
- raum.
Cov tsos mob ntawm cov poj niam:
- ib cov kab mob uas ua rau cov nqaij tawv (cov tawv nqaij reticulated);
- myocardial infarction;
- migraines;
- kev tuag;
- mob hauv siab;
- varicose leeg;
- tus kab mob thrombophlebitis;
- mob stroke;
- arterial hypertension;
- mob raum tsis zoo;
- ascites;
- ischemic tawm tsam ;
- hnoos qhuav heev;
- necrosis ntawm cov pob txha thiab cov nqaij mos;
- portal hypertension;
- txoj hnyuv tws ntshav;
- mob loj heev;
- tus pwg infarction;
- mob hauv plab hlo hauv plab;
- mob me me.
Antiphospholipid Syndrome - mob
Nws tsis yooj yim kom paub meej tias muaj cov kab mob uas tau piav qhia, vim hais tias nws qhov ncauj qhov ntswg rau lwm cov kab mob, muaj cov kab mob tsis tseem ceeb. Rau kev kuaj mob tus kabmob, cov kws kho mob siv 2 pawg kev faib haujlwm. Ib qho kev kuaj mob rau cov tshuaj antiphospholipid syndrome thawj zaug yog khaws cov tshuaj anamnesis. Thawj hom kev ntsuas kev ntsuas muaj xws li soj ntsuam cov xwm txheej:
- Vascular thrombosis. Cov keeb kwm kev mob nkeeg yuav tsum muaj ib los yog ntau tus neeg raug mob los ntawm cov leeg lossis cov hlab ntsha uas tsim muaj kev ntsuas thiab kev sim.
- Obstetrical pathology. Qhov ntsuas tau muab suav rau hauv qhov yog tias kev tuag ntawm tus me nyuam hauv plab tom qab lub hnub nyoog 10 ntawm gestation los yog yug ua ntej yug tau ua ntej 34 lub lis piam ntawm gestation thaum tsis muaj chromosomal, hormonal thiab anatomical defects los ntawm niam txiv.
Tom qab tau muab cov keeb kwm kho mob tas lawm, tus kws kho mob tau tso cai ntxiv. Antiphospholipid syndrome yog paub tseeb thaum muaj kev sib txuam ua ke ntawm ib qho kev kuaj mob thiab ib qho kev sim (tsawg). Nyob rau hauv parallel, ib tug xov tooj ntawm sib txawv diagnostic ntsuas raug nqa tawm. Rau qhov no, tus kws kho mob pom zoo tias koj yuav mus kuaj mob uas tshem tawm cov kab mob zoo sib xws.
Antiphospholipid Syndrome - tsom xam
Kev kuaj kom pom tias muaj cov kab mob hauv lub cev tam sim no yog ua los ntawm kev tshawb fawb ntawm cov roj ntsha. Tus kws kho mob tso cai muab ntshav rau antiphospholipid syndrome los txiav txim seb muaj ntshav qab zib thiab ntshav cov tshuaj tiv thaiv rau cardiolipins thiab lupus anticoagulant. Ntxiv mus, cov nram no tuaj yeem kuaj tau:
- cryoglobulins;
- tshuaj mus rau erythrocytes;
- T- thiab B-lymphocytes hauv cov concentration ntxiv;
- antinuclear thiab rheumatoid yam.
Qee lub sij hawm qhov kev tshawb nrhiav pom tau hais tias tso cai rau nrhiav cov cim ntawm antiphospholipid syndrome:
- HLA-DR7;
- HLA-B8;
- HLA-DR2;
- DR3-HLA.
Yuav kho tus mob antiphospholipid syndrome no li cas?
Txoj kev kho ntawm qhov kev puas siab puas ntsws oob khab no nyob ntawm nws daim ntawv (thawj, theem nrab) thiab qhov hnyav ntawm kev kuaj mob. Cov teeb meem tshwm sim yog tias tus poj niam cev xeeb tub muaj antiphospholipid syndrome - kev kho mob yuav tsum ua kom tsis txhob muaj cov tsos mob ntawm tus kab mob, tiv thaiv thrombosis, thiab hauv kev ua kom tsis muaj teeb meem rau tus me nyuam hauv plab. Yuav kom ua tiav cov kev txhim kho, cov rheumatologists siv kev kho mob ua ke.
Puas yuav ua tau kom kho tau tus mob antiphospholipid syndrome?
Ua tib zoo tshem tau qhov teeb meem tau piav meej yog tsis yooj yim sua, txog thaum ua rau nws tshwm sim. Antiphospholipid syndrome yuav tsum kho txoj hauv kev kom txo cov nab npawb ntawm cov tshuaj tiv thaiv kab mob hauv cov ntshav thiab tiv thaiv kom tsis txhob muaj teeb meem ntawm cov mob thromboembolic. Nyob rau hauv loj chav kawm ntawm tus kab mob, anti-inflammatory kho yog yuav tsum tau.
Kev kho mob ntawm antiphospholipid syndrome - kev pom zoo tam sim no
Lub ntsiab txoj hauv kev mus tshem tawm cov cim qhia ntawm qhov kev qog no yog kev siv cov antiaggregants thiab anticoagulants ntawm qhov kev txiav txim indirect:
- Acetylsalicylic acid (Aspirin thiab analogues);
- Warfarin ;
- Acenocoumarol;
- Phenylin;
- Dipyridamole.
Yuav ua li cas kho antiphospholipid syndrome - cov lus qhuab qhia:
- Tsis kam haus luam yeeb, haus cawv thiab siv yeeb siv tshuaj, qhov ncauj tiv thaiv kab mob hauv qhov ncauj.
- Kho cov zaub mov hauv cov zaub mov nplua nuj nyob hauv vitamin K - ntsuab tshuaj yej, nplooj siab, nplooj ntsuab nplooj.
- Ua kom tiav so, saib lub regime ntawm hnub ntawd.
Yog hais tias tus txheej txheem kho tsis zoo, qhov kev xyaum siv tshuaj ntxiv yog:
- aminoquinolines - Plaquenil, Delagil;
- ncaj qha tshuaj anticoagulants - Clexan , Fraxiparin;
- glucocorticoids - Prednisolone , Methylprednisolone;
- inhibitors ntawm platelet receptors - Tagren, Clopidogrel;
- heparinoids - Emeran, Sulodexide;
- cytostatics - Endoxane, Cytoxan;
- immunoglobulins (cov thawj coj hauv lub cev).
Traditional tshuaj nrog antiphospholipid syndrome
Nws tsis muaj lwm txoj hau kev rau kev kho mob, qhov kev xaiv tsuas yog qhov hloov ntawm acetylsalicylic acid nrog tej yam khoom raw. Antiphospholipid syndrome tsis tuaj yeem raug tso tseg nrog kev pab ntawm cov neeg noj zaub mov txawv, vim tias cov tshuaj anticoagulants muaj cov nyhuv me me. Ua ntej siv lwm txoj kev txhais tau tias nws yog ib qho tseem ceeb rau sab laj nrog ib tug kws kho mob. Tsuas yog tus kws kho mob yuav pab txo kom tus mob antiphospholipid syndrome xwb - tus kws kho mob cov lus pom zoo yuav tsum tau pom tseeb.
Tshuaj yej nrog cov tshuaj aspirin
Cov khoom xyaw:- qhuav bark ntawm dawb willow - 1-2 tsp.
- boiling dej - 180-220 ml.
Npaj, siv :
- Zaub raw khoom kom huv si yaug thiab zom.
- Brew doow bark nrog boiling dej, insist 20-25 feeb.
- Haus kua tshuaj yeem xws li tshuaj yej 3-4 zaug ib hnub twg, koj tuaj yeem noj qab haus huv.
Antiphospholipid syndrome - qhov kev mob
Tag nrho cov neeg mob rheumatologist nrog tus kws kho mob hais no yuav tsum tau pom ntev ntev thiab tsis tu ncua kev kuaj mob. Kuv yuav ua neej nyob ntev li cas nrog ib qho mob antiphospholipid syndrome, nyob ntawm nws daim ntawv, qhov mob hnyav thiab muaj cov kab mob hauv lub cev tiv thaiv kab mob. Yog tias APS thawj uas muaj cov tsos mob tshwm sim tsawg, qhov kev kho mob tsis tu ncua thiab kev tiv thaiv kev tiv thaiv kom tsis txhob muaj teeb meem, qhov kev txiav txim ntawm cov xwm txheej zoo li yog qhov zoo tshaj plaws.
Kev mob nyhav nyhav yog ua ke ntawm tus kab mob uas nug txog nrog lupus erythematosus, thrombocytopenia, persistent arterial hypertension and other pathologies. Hauv cov xwm txheej no, feem ntau ua rau tus mob antiphospholipid syndrome (catastrophic), uas yog cov tsos mob ntawm tus kab mob thiab cov tsos mob rov muaj dua. Qee qhov kev rau txim yuav kawg tuag tau.
Antiphospholipid syndrome thiab cev xeeb tub
Tus kab mob uas tau piav qhia yog ib qho ua rau me nyuam me, yog li txhua tus niam tom ntej yuav tsum tau mus soj ntsuam ib qho kev ntsuam xyuas thiab pub ntshav rau ib coagulogram. Antiphospholipid syndrome nyob rau hauv obstetrics yog suav hais tias yog ib qho tseem ceeb uas ua rau me nyuam tuag ploj thiab tuag taus, tab sis nws lub xub ntiag tsis yog qhov kev txiav txim. Ib tug pojniam uas muaj tus kab mob li no nws muaj peev xwm los yug thiab yug tus me nyuam noj qab nyob zoo yog tias thaum lub caij nws cev xeeb tub nws yuav ua raws li tag nrho tus kws kho mob cov lus pom zoo thiab siv tshuaj tiv thaiv.
Ib qho qauv zoo sib xws yog siv thaum tsim cov khoom ntim tawm. Antiphospholipid syndrome thiab IVF yog kiag li tshaj plaws, tsuas yog lawv yuav tsum tau nkag mus hauv ib hom tshuaj antithrombotic. Kev siv cov tshuaj anticoagulants thiab cov tshuaj antiaggregants yuav ua mus ntxiv nyob rau tag nrho lub sijhawm ntawm kev ua niam txiv. Txoj kev ua haujlwm zoo li no yog nyob ze rau 100%.