Cov tshuaj tua kab mob Cytotoxic yog ib pawg ntawm cov tshuaj uas nws qhov kev txiav txim siab yog tswj kev tiv thaiv los yog inhibiting cov txheej txheem ntawm cov kev faib cell cell thiab kev loj hlob ntawm cov nqaij ntshiv.
Thaum twg yog cytostatics kws kho mob?
Lub ntsiab lus ntawm daim ntawv thov ntawm cov tshuaj nyob rau hauv nqe lus nug yog kev kho mob malignant qog uas yog characterized mob siab khaus (untreated cell division) (cancer, leukemia , lymphomas, thiab lwm yam).
Yuav kom tsawg zog, qhov teeb meem ntawm cov tshuaj hauv cov pab pawg no yuav raug qaug zog ntawm cov pob txha pob txha, tawv nqaij, mucous membranes, epithelium ntawm txoj hnyuv. Qhov no tso cai rau kev siv cov cytostatics hauv cov kab mob autoimmune (rheumatoid mob caj dab, scleroderma, lupus nephritis, Goodpasture's disease, mob ntsws lupus erythematosus, thiab lwm yam).
Ua ib feem ntawm txoj kev kho, cov tshuaj cytotoxic tuaj yeem siv tshuaj pleev rau hauv daim ntawv ntawm cov ntsiav tshuaj, tshuaj ntsiav, lossis cov tshuaj (intravenous, intra-arterial, intraluminal, intravitreal). Lub sij hawm ntawm kev kho mob yog txiav txim siab los ntawm ntau ntawm tus kab mob, qhov ua tau zoo thiab tolerability ntawm yeeb tshuaj.
Sau cov tshuaj cytotoxic
Cytostatics yog cais rau qhov laj thawj ntawm kev txiav txim, thiab qhov kev cais no yog cai, vim tias ntau cov tshuaj uas muaj rau tib pab pawg muaj cov tswv yim sib txawv ntawm cov kev txiav txim thiab muaj peev xwm tiv thaiv tsis pub muaj ntau hom qog nqaij hlav. Ntawm no yog qhov tseem ceeb ntawm cov npe ntawm cov yeeb tshuaj cytotoxic:
1. Siv yeeb tshuaj:
- alkylsulfonates (Busulfan, Treosulfan);
- ethylenimines (Thiotepa);
- derivatives ntawm nitrosoureas (Nimustine, Lomustine, Carmustine, Mystophoran, Streptozotocin);
- chloroethylamines (Chlorambucil, Ifosfamide, Bendamustine, Cyclophosphamide, Melphalan, Trophosphamide).
2. Alkaloids ntawm cog keeb kwm:
- podophyllotoxins (Teniposide, Etoposide);
- taxanes (docetaxel, paclitaxel);
- vinaalkaloids (Vindesin, Vincristine, Vinblastine, Vinorelbine).
3. Antimetabolites:
- antagonists ntawm folic acid (Ralitrexed, Methotrexate);
- Purine antagonists (Cladribine, Fludarabine, Pentostatin, Thioguanine);
- antagonists ntawm pyrimidine (cytarabine, capecitabine, gemcitabine, fluorouracil).
4. Tshuaj tua kab mob nrog tshuaj tiv thaiv:
- anthracyclines (Doxorubicin, Daunorubicin, Epirubicin, Idarubicin, Mitoxantrone);
- lwm yam tshuaj antibiotics (mitomycin, bleomycin, plikamycin, dactinomycin).
5. Lwm cov cytostatics:
- derivatives ntawm camptothecin (Irinotecan, Topotecan);
- derivatives ntawm platinum (Cisplatin, Carboplatin, Oxaliplatin);
- lwm tus (Temozolomide, Altrethamine, Estramustine, Amsacrine, L-asparaginase, Dacarbazine, Hydroxycarbamide, Procarbazine).
6. Tshuaj tua kab mob Monoclonal (Trastuzumab, Ederkolomab, Rituximab).
7. Cov tshuaj hormones qis:
- tshuaj tua kab mob (cyproterone acetate, bicalutamide, flutamide);
- progestins (Medroxyprogesterone acetate, Megestrol acetate);
- estrogens (Polyestradiol, Phosphastrol);
- antiestrogens (Toremifene, Tamoxifen, Droloxifene);
- aromatase inhibitors (Anastrozol, Formestan, Exemestane).
- LH-RH agonists (Gocerelin, Buserelin, Leiprolein acetate, Tryptorelin).
Tus kab mob Cytotoxic pancreatitis
Thaum mob loj, cytostatics (xws li, fluorouracil) tuaj yeem siv rau kev kho mob. Lub hom phiaj ntawm kev ua ntawm cov tshuaj no yog txuam nrog lawv kev muaj peev xwm los tiv thaiv kev ua qias neeg ntawm pancreatic hlwb.
Lwm cov teeb meem ntawm Cytostatics
Cov kev mob tshwm sim hauv kev kho cov cytostatics yog:
- poob plaub hau;
- zawv plab;
- anorexia ;
- xeev siab;
- ntuav;
- mob taub hau;
- leeg tsis muaj zog;
- ua txhaum ntawm kev coj khaub ncaws;
- infertility;
- kev loj hlob ntawm leukemia, lwm yam zoo li