Aminoglycosides muaj xws li ib pawg tshuaj tua kab mob uas ua los ntawm ib tus qauv zoo sib xws, txoj cai ntawm kev ua haujlwm thiab muaj kev sib tov tshuaj. Cov tshuaj Aminoglycoside muaj cov tshuaj tua kab mob antimicrobial thiab tawm tsam Gram-positive thiab Gram-negative bacteria.
Kev faib tawm ntawm aminoglycosides
Nyob ntawm thaj chaw ntawm daim ntawv thov thiab zaus ntawm kev loj hlob ntawm kev tawm tsam, plaub tiam ntawm kev siv yeeb siv tshuaj. Cia peb xav txog cov yam ntxwv yooj yim thiab peb yuav ua rau cov npe ntawm cov kev npaj-aminoglycosides.
Thawj Cov Tshuaj Ua Ntej
Cov no yog:
- Neomycin;
- Streptocin;
- Monomycin;
- Kanazin.
Lawv siv tshuaj kho tawm tsam cov kab mob ntawm tuberculosis thiab qee cov kab mob atypical. Tawm tsam staphylococci thiab feem ntau cov kab mob gram-negative, cov tshuaj tsis muaj zog. Tam sim no lawv suab tsis siv.
Aminoglycosides ntawm ob tiam neeg
Tus neeg sawv cev ntawm pawg thib ob ntawm cov tshuaj tiv thaiv kab mob-aminoglycoside yog Gentamicin, uas muaj ntau yam tshaj li cov pab pawg neeg dhau los ntawm cov tshuaj.
Qhov thib peb tiam ntawm aminoglycosides
Lub spectrum ntawm peb lub cim tiam sis zoo ib yam li Gentamycin, tiam sis lawv zoo dua tiv thaiv enterobacter, klebiciella thiab Pseudomonas aeruginosa . Pab pawg no muaj xws li:
- Sisomycin;
- Tobramycin;
- Amicacin.
Plaub tiam
Pawg no suav nrog cov tshuaj tua kab mob Izepamycin, uas ntxiv rau muaj peev xwm sib ntaus nrog nocardia, cytobacter, aeromonas.
Qhov mob ntawm aminoglycoside
Thaum lub sij hawm kho mob nrog cov tshuaj no, tus neeg mob tej zaum yuav ntsib ib co kev xav tsis zoo uas tshwm sim. Lub ntsiab drawback ntawm cov tshuaj yog toxicity. Nws tshwm sim nws tus kheej hauv cov kev tshwm sim hauv qab no:
- Ototoxicity, uas ua rau ib tug poob rau hauv lub qhov hnyav ntawm lub rooj sib hais, qhov zoo li ntawm lub suab nrov hauv pob ntseg, zoo nkaus li muaj kev ntxhov siab.
- Nephrotoxic effect, tshwm sim ntawm qhov uas nqhis, hloov zis, txo cov glomerular pom.
- Kev ua kom sib haum ntawm kev taw thiab kiv taub hau, uas yog yam ntxwv tshwj xeeb tshaj ntawm cov neeg laus.
- Nyob rau ntawm qhov chaw ntawm lub paj hlwb, loog hauv lub qhov ncauj, loog, tsis muaj zog, mob taub hau, nruj kev sib tw, kev tsaug zog.
- Cov tsos mob ntawm cov tsos mob ntawm cov hlab ntsha paj hlwb, ua rau muaj kev ntxhov siab txog kev ua pa ntawm lub cev, ua rau lub cev tsis muaj zog, nrog rau cov tshuaj tua kab mob ntawm cov tshuaj tua kab mob-aminoglycoside nrog cov leeg mob thiab cov tshuaj loog, thiab ntxiv ntshav nrog citrated ntshav.
Cov tsos mob ntawm cov tshuaj tiv thaiv tsis haum yog tsawg.