Hauv cov kab mob uas muaj cov kab mob tsis paub los yog cov kab mob sib xyaw (microbes, fungi), tshuaj siv nrog qhov dav ntawm kev ua ub no yog qhov tsim nyog. 5-NOC yog ib tug kab mob antibacterial ua haujlwm tiv thaiv kab mob siab tshaj plaws. Nws yog zoo tiv thaiv ib co mycoses.
5-NOC - muaj pes tsawg leeg
Lub ntsiab ntawm cov tshuaj nyob rau hauv nqe lus nug yog nitroxoline. Nws yog ib qho tshuaj lom derivative ntawm 8-hydroxyquinoline, nws inhibits cov synthesis ntawm DNA ntawm cov hlwb pathogenic thiab tiv thaiv lawv cov tub ntxhais. Cov txheej txheem ntu kuj muaj nyob rau hauv 5-NOC-ntsiav tshuaj yog:
- lactose monohydrate;
- calcium hydrogen phosphate;
- cov hmoov nplej siab pob kws;
- Povidone K25;
- colloidal silicon dioxide;
- lim tiam;
- magnesium stearate;
- kev kuaj mob.
Kuaj cov tshuaj nyob rau hauv lub plhaub tiv thaiv, uas muaj cov nram qab no:
- carmellose sodium;
- acacia cov pos hniav;
- colloidal silicon dioxide;
- Povidone K25;
- titanium dioxide;
- cov hmoov nplej siab pob kws;
- sucrose;
- lim tiam;
- calcium carbonate;
- zaub mov xim - daj "Sunset Sunset" (E110) thiab quinoline (E104).
5-NOC - qhov tseem ceeb
Cov tshuaj no yog npaj rau kev kho mob ntawm tus kab mob ntsws los sis qeeb rov qab los ntawm cov kab mob hauv lub cev thiab cov kev ua me nyuam. Tablets 5-NOC yuav pab tiv thaiv cov kab mob xws li:
- Gram-zoo aerobic thiab kev sib hlub;
- gram-tsis zoo aerobic thiab kev sib hlub;
- mycoplasma ;
- ureaplasma ;
- Trichomonas;
- Mycobacterium tuberculosis;
- dermatophytes;
- pwm cov pwm;
- neeg sib tw;
- pathogens provoking deep thiab loj mycoses.
5-NOC - qhov taw qhia rau kev siv:
- cystitis;
- pyelonephritis ;
- epididymitis;
- mob caj pas;
- tus kab mob muaj tus kab mob (adenoma, carcinoma) ntawm prostate;
- prostatitis;
- inflammatory processes nyob rau hauv lub zais zis los yog ntsaws kab mob.
Cov lus piav qhia yog siv los tiv thaiv tus kab mob rau hauv xws li:
- postoperative lub sij hawm;
- kev tshawb nrhiav kev ntsuas;
- cystoscopy ;
- catheterization.
5-NOC - phiv tshuaj
Cov tshuaj tiv thaiv kab mob muaj zog tuaj yeem ua rau muaj kev cuam tshuam tsis zoo ntawm lub cev los ntawm lwm qhov. Qhov no txhais tau tias tsis tshua muaj tshwm sim rau cov kev mob tshwm sim. Hauv cov rooj plaub tshwj, 5-NOC npaj ua rau:
- tachycardia;
- ntuav;
- anorexia;
- xeev siab;
- impaired daim siab ua haujlwm;
- kiv taub hau;
- optic neuritis (nrog rau kev siv sijhawm ntev);
- niam txiv lub cev;
- tsis ua haujlwm;
- mob taub hau;
- polyneuropathy;
- tus kab mob thrombocytopenia;
- nce concentration ntawm uric acid;
- urticaria;
- khaus ntawm daim tawv nqaij;
- ataxia;
- staining lub zis rau hauv nplua nuj xim daj.
5-NOC contraindications
Qhov cuab yeej no tsis raug pom zoo rau tus kheej tsis txaus ntseeg rau ib qho ntawm cov khoom xyaw uas teev saum toj saud, nrog rau cov tshuaj chiv pabcuam thiab cov khoom khauj khaum. Tus 5-NOC yeeb tshuaj tiv thaiv kab mob hauv qab no:
- cev xeeb tub;
- cataract;
- pub niam mis;
- kev cuam tshuam loj heev ntawm lub siab los yog lub raum nrog ib tus cwj pwm (creatinine clearance) tsawg dua 20 ml / min (qhia tsis tshua muaj, nrog ceev faj);
- hnub nyoog txog 3 xyoos.
Yuav ua li cas noj 5-NOC ntsiav tshuaj?
Cov txheej txheem txhua txhua hnub ntawm kev noj tshuaj yog nyob ntawm lub hnub nyoog thiab muaj cov kab mob ntev. Cov laus ib hnub yuav tsum tau siv 400 mg ntawm cov tshuaj 5-NOC - daim ntawv thov yuav siv cov tshuaj no, faib ua 4 zaug, 100 mg (2 ntsiav tshuaj) ua ntej noj mov. Nrog rau cov kab mob muaj zog, muaj li ob zaug (800 mg). Cov me nyuam muaj hnub nyoog 5 xyoos rov saud 200-400 mg tshuaj txhua 24 teev, thiab cov me nyuam muaj hnub nyoog 3-5 xyoos - 200 mg. Feem ntau ntawm kev kho mob tsis tshaj 2-4 lub lim piam, yog tias tsim nyog, rov ua dua.
Nrog 5-NOC yog siv nrog kev xyuam xim tshaj plaws - qhia tau tias tsis siv cov kab mob no, tab sis thaum muaj mob hnyav, ib qho tshuaj tua kab mob tuaj yeem kho tau. Hauv cov no, siv 1 lub tshuaj 4 zaug ib hnub twg. Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam cov tshuaj tiv thaiv ntawm lub raum thiab lub siab rau kev kho mob thiab saib xyuas cov qib creatinine clearance.
5-NOC - ib daim ntawv thov rau cystitis
Kev noj tshuaj ntawm cov tshuaj tua kab mob antimicrobial sib raug mus rau ib hom tshuaj ntawm 400 mg nitroxoline txhua 24 xuab moos. 5-NOC nrog cystitis yog kev pom zoo ntawm 10-21 hnub. Lub caij nyoog kho ntawm txoj kev kho yog suav los ntawm ib tug kws kho mob ntawm cov tshuaj ntsuam xyuas, kev kuaj mob loj heev, thiab muaj kev phiv los ntawm kev kho mob. Qee lub sij hawm nws yuav tsum muab txuas rau 1 lub hlis, tshwj xeeb tshaj yog yog hais tias tus kab mob ua ke los yog theem nrab.
5-NOC nrog pyelonephritis
Cov lus piav qhia hauv cov ntawv ntxim yuav tsum kom luv luv ntawm cov tshuaj tua kab mob, 400 mg txhua hnub rau 2-2.5 lub lim tiam. Nyob rau hauv kev kawm ntev ntawm cov kab mob pyelonephritis, cov urologist txiav txim seb yuav siv li cas 5-NOC. Muaj cov tswv yim ntawm kev kho mob ntev ntev (2-3 hli rau 14 hnub) thiab cov kab mob nrog ntev ntev ntawm kev siv tshuaj nyob rau hauv qis dua (100-200 mg).
Qee lub sij hawm nws yuav siv qhov ntev tshaj plaws ntawm 5-NOC - qhov taw qhia rau kev siv muaj xws li cov mob hnyav pyelonephritis:
- xanthogranulomatous;
- purulent;
- ntsuas.
5-NOC thaum cev xeeb tub
Thoob plaws lub sij hawm gestation, tus poj niam txoj kev tso zis yuav muaj kev ywj pheej heev thiab yog ib qho ua rau lub cev muaj zog tiv thaiv. Vim li no, cov niam txiv yeej xav tau 5-NOC - Kuv haus tau nws thaum lub caij nws cev xeeb tub thiab hauv cov khoom noj li cas. Qhov tshuaj tua kab mob no tiv thaiv rau hauv qhov teeb meem no, vim tias nws tuaj yeem cuam tshuam rau txoj kev loj hlob lossis tsim tawm ntawm tus me nyuam hauv plab.
5-NOC analogues
Thaum cov tshuaj antimicrobial tshuaj tsis tuaj yeem siv los yog nws ua rau muaj kev phom sij loj heev, nws yuav tau muab tso tseg. Tib txoj kev los hloov cov 5-NOC ntsiav tshuaj yog siv cov qauv zoo tib yam lossis cov khoom siv. Muaj ob qho tib si analogs rau cov tshuaj piav qhia:
- Nitroxoline (Yelemees, Russia);
- Uroksolin (Ukraine).
Thawj cov tshuaj yog tsim nrog ntau yam sib txawv ntawm cov khoom muaj nyob rau hauv, uas yog yooj yim rau txoj kev kho mob nrog ntau dua. Qhov thib ob tshuaj tsuas yog nyob rau hauv cov ntsiav tshuaj nrog ib qho tshuaj lom neeg cov ntsiab lus ntawm 50 mg. Yog tias tsis pom zoo rau nitroxinolin los yog nws cov dej caw, nws yuav tsum siv cov generic. Cov tshuaj no muaj cov yeeb yam zoo li qub nrog 5-NOC - qhov tseem ceeb rau kev siv, tua cov kab mob thiab tshuaj tua kab mob, tiam sis txawv txav. Cov tshuaj siv tau zoo nyob hauv daim ntawv ntawm bacteriophages:
- dysentery polyvalent;
- hnyuv quav;
- yog tias;
- staphylococcal;
- Protein;
- Klebsiella pneumonia;
- Pseudomonas (pseudomonas);
- kolik-proteyny;
- salmonella.
Lwm cov generics nrog cov cim zoo tib yam:
- Fosmicin;
- Ureacid;
- Fosmural;
- Bernie;
- Fosmicin;
- Monural;
- Phosphoral;
- Urophosfabol;
- Khauj;
- Plaub Hlis;
- Urofoscin;
- Phosphocin;
- Espa-Focine.