17-OH progesterone los yog 17-hydroxyprogesterone yog ib yam tshuaj hormone steroid uas yog ua rau cov cortical quav ntawm lub caj dab neeg adrenal thiab yog lub phais ntawm cov tshuaj hormones li cortisol, estradiol thiab testosterone. Nws kuj ua rau cov qog nqaij hlav, qhov nqaij mos, lub cev daj thiab lub tsho me thiab nyob rau hauv tus cawv ntawm 17-20 lyase dhau los ua kev sib deev hormones. Tom ntej no, peb yuav xav txog lub luag hauj lwm ntawm lub 17-progesterone plays lub cev ntawm tus poj niam tsis xeeb tub thiab thaum cev xeeb tub thiab cov tsos mob ntawm nws nce thiab tsis muaj peev xwm.
Txheeb raws roj ntsha ntawm cov tshuaj hormones 17-oh progesterone
Txhua tus neeg qib ntawm 17-OH progesterone fluctuates tsis pub dhau 24 teev. Li ntawd, nws cov concentration ntau tshaj yog teev nyob rau hauv thaum sawv ntxov teev, thiab qhov tsawg kawg nkaus - nyob rau hauv lub hmo ntuj. 17-OH progesterone rau cov poj niam sib txawv nyob ntawm theem ntawm kev coj khaub ncaws. Qhov siab tshaj plaws nce nyob rau theem ntawm no hormone yog muab sau rau ntawm lub tsev ntawm ovulation (ua ntej qhov siab tshaj plaws nce hauv luteinizing hormone). 17-OH progesterone hauv qib follicular txo tsawg zuj zus, ncav qib qis tsawg kawg hauv cov theem ntawm ovulation.
Tam sim no xav txog qhov tseem ceeb ntawm 17-OH progesterone, nyob ntawm seb cov theem ntawm kev coj khaub ncaws:
- nyob rau theem luteal - 0.99-11.51 nmol / l;
- nyob rau hauv theem follicular - 1,24-8,24 nmol / l;
- nyob rau hauv lub sij hawm ntawm ovulation - 0,91-4,24 nmol / l.
17-OH progesterone thaum cev xeeb tub nce, ncav nws qhov tseem ceeb tshaj plaws hauv lub lis piam dhau los. Thaum lub caij cev xeeb tub, lub tsho me nyuam kuj tseem tuaj yeem teb rau qhov kev sib tw ntawm no cov tshuaj steroid. Xav txog tus nqi tso cai ntawm 17-OH progesterone thaum cev xeeb tub:
- hauv thawj peb lub hlis - 3,55-17,03 nmol / l;
- nyob rau hauv ob lub trimester - 3,55-20 nmol / l;
- nyob rau hauv peb lub hlis trimester - 3.75-33.33 nmol / l.
Hauv premenopausal thiab thaum lub cev ntas, qib theem ntawm 17-OH progesterone txo qis thiab nce mus txog 0.39-1.55 nmol / l.
Hloov hauv qib 17-OH progesterone - kuaj mob thiab cov tsos mob
Qib theem ntawm 17-OH progesterone nyob rau hauv cov ntshav feem ntau yog qhov ua rau ntawm adrenal hypoplasia thiab muaj peev xwm ua ke nrog cov khoom tsis txaus los ntawm lwm cov tshuaj hormones. Clinically, nws muaj peev xwm manifest nws tus kheej nyob rau hauv daim ntawv ntawm Addison tus kab mob, thiab cov tub hluas underdevelop lub sab nraud genitalia.
Qhov nce hauv 17-OH progesterone tuaj yeem raug cai tsuas yog thaum cev xeeb tub xwb, lwm zaus nws qhia tias pathology. Yog li, tus kws kho mob siab 17-OH progesterone tuaj yeem yog ib yam kabmob ntawm cov hlav adrenal, zes qe menyuam (malignant formations thiab polycystosis) thiab mob caj pas hauv adrenal cortex.
Kuaj raws li, qhov nce hauv 17-OH progesterone tuaj yeem tshwm sim tau:
- ua txhaum ntawm kev coj khaub ncaws;
- infertility;
- Tshwm sim abortions;
- thaum tsis muaj hnub nyoog los yog me nyuam mos liab thaum ntxov;
- ib qho kev nce rau hauv progesterone 17-OH tej zaum yuav tshwm sim los ntawm pob txuv (ntxau);
- Yog tias 17-OH progesterone nce siab, testosterone tuaj yeem ua tau zoo ntxiv. Qhov no tuaj yeem tshwm sim nyob rau hauv daim ntawv ntawm kev loj hlob kev loj hlob ntawm cov plaub hau ntawm lub ntsej muag thiab lub cev (txiv neej plaub hau hom).
Cov theem ntawm 17-OH progesterone tuaj yeem txiav txim tau los ntawm kev kuaj ntshav
Yog li, peb tau kuaj xyuas txog kev txheeb li biological hauv lub cev ntawm cov tshuaj hormone 17-OH progesterone thiab nws cov cai raug cai rau cov poj niam. Qhov kev txo qis nyob rau theem ntawm qhov hormone no feem ntau yuav tsuas yog thaum lub sij hawm ntuav, thiab nws qhov kev xav tau pom zoo thoob plaws hauv plab. Cov kev hloov hauv qib 17-OH progesterone lwm tus kuj yog ib qho ntawm cov tsos mob ntawm tus kab mob hu ua adrenal thiab ovarian, uas ua rau hyperandrogenism, infertility los yog spontaneous abortions.